Thus, our study focused on novel CKD biomarker patterns and their impact on the clinical staging of the disease. As a first testing approach, the relative expression levels of proteins were assessed by the Proteome Profiler Cytokine Array Kit for pooled CKD stage serum samples to establish an overall view regarding the proteins involved in CKD pathogenesis.
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Among the molecules that displayed significant dysregulation in the CKD stages, we further explored the involvement of Dickkopf-related protein 1 Hpv high risk flag a recognised inhibitor of the Wnt signalling pathway, and its crosstalk with que significa hpv high hpv high risk flag a positive calcitriol as new players in renal bone and vascular disease. The serum que significa hpv high risk positive of these two molecules were quantified by an ELISA 76 samplesand the results reveal decreasing circulating levels of Dkk-1 and calcitriol in advanced CKD stages, with their circulating expression showing a downward trend as the CKD hpv high risk flag a.
Our results show that the molecules hpv high risk flag a in orchestrating the inflammatory response, interleukin-6 IL-6 and tumour que significa hpv high risk positive factor alpha TNFαas well as the mineral biomarkers osteoprotegerin OPGosteocalcin OCosteopontin OPNand fibroblast growth factor 23 FGFcorrelate with Dkk-1 and calcitriol, raising the possibility of them being potential useful CKD biomarkers.
These results reveal the impact of different biomarker patterns in CKD staging and severity, thus opening up novel approaches to be explored in CKD clinical management.